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Bruen, et. al. 2007. Reduction of the incidence of amputation in frostbite injury with thrombolytic therapy. Arch Surg, 142, 546-553.
Twomey, Peltier, & Zera. 2005. An open-label study to evaluate the safety and efficacy of tissue plaminogen activator in treatment of severe frostbite. The Journal of Trauma Infection, Infection, and Critical Care, 59(6), 1350-1355.